NCI-H460 cells were subjected to SDS PAGE followed by western blot with FNab08301(STAT4 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat kidney using FNab08301(STAT4 antibody) at dilution of 1:100
Background
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.